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Data and pipelines associated with manuscripts are available on GitHub and other public servers.

Corresponding Author(s)   § co-First Authors   co-Senior Authors    Lab Members
2022 Gallo KJ, Wheeler NJ, Elmi AM, Airs PM, Zamanian M
Pharmacological profiling of a Brugia malayi muscarinic acetylcholine receptor as a putative antiparasitic target.

2022 Wheeler NJ, Ryan KT, Gallo KJ, Henthorn CR, Ericksen SS, Chan JD, Zamanian M
Multivariate chemogenomic screening prioritizes new macrofilaricidal leads.
    • /zamanianlab/MultivariateScreening-ms

2022 Wheeler NJ, Gallo KJ, Garncarz E, Ryan KT, Chan JD, Zamanian M
wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms.
    • zamanianlab/wrmXpress
    • Docker: zamanianlab/chtc-wrmxpress
    • Zenodo: 10.5281/zenodo.6558304

2022 Wheeler NJ, Hallem EA, Zamanian M
Making sense of sensory behaviors in vector-borne helminths.
Trends in Parasitology

2022 Airs PA, Vaccaro K, Gallo KJ, Dinguirard N, Heimark ZW, Wheeler NJ, He J, Weiss KR, Schroeder NE, Huisken J, Zamanian M
Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayi.
PLoS Pathogens
    • /zamanianlab/BrugiaSpatial-ms
    • NIH Bioprojects: PRJNA548881

2021 Zamanian M, Chan JD.
High-content approaches to anthelmintic drug screening.
Trends in Parasitology

2021 Evans KS, Wit J, Stevens L, Hahnel SR, Rodriguez B, Park G, Zamanian M, Brady SC, Chao E, Introcaso K, Tanny RE, Andersen EC.
Two novel loci underlie natural differences in Caenorhabditis elegans abamectin responses.
PLoS Pathogens

2020 Wheeler NJ, Airs PM, Zamanian M.
Long-read RNA sequencing of human and animal filarial parasites improves gene models and discovers operons.
PLoS Negl Trop Dis
    • /zamanianlab/Filarid_IsoSeq-ms
    • /zamanianlab/polyAudit
    • NIH Bioprojects: PRJNA548902 (B. malayi); PRJNA640410 (D. immitis)

2020 Loghry HJ, Yuan W, Zamanian M, Wheeler NJ, Day TA, Kimber MJ.
Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes.
Journal of Extracellular Vesicles

2020 Nixon S, Welz C, Woods D, Costa-Junior L, Zamanian M, Martin RJ.
Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics.
Int Journal for Parasitology: Drugs and Drug Resistance

2020 Wheeler NJ, Heimark ZW, Airs PM, Mann A, Bartholomay LC, Zamanian M.
Genetic and functional diversification of chemosensory pathway receptors in filarial nematode parasites.
PLoS Biology
    • /zamanianlab/BrugiaChemo-ms
    • NIH Bioprojects: PRJNA548881; PRJNA548902

2019 Maier T, Wheeler NJ, Namigai EK, Tycko J, Grewelle RE, Woldeamanuel Y, Klohe K, Perez-Saez J, Sokolow SH, De Leo GA, Yoshino TP, Zamanian M, Jutta Reinhard-Rupp✚‡.
Gene drives for schistosomiasis transmission control.
PLoS Negl Trop Dis

2019 International Helminth Genomes Consortium (Coghlan A, Tyagi R, Cotton JA, Holroyd N, Rosa BA, Tsai IJ, Laetsch DR, Beech RN, Day TA, Hallsworth-Pepin K, Ke H, Kuo T, Lee TJ, Martin J, Maizels RM, Mutowo P, Ozersky P, Parkinson L, Reid AJ, Rawlings ND, Ribeiro DM, Swapna LS, Stanley E, Taylor DW, Wheeler NJ, Zamanian M, Zhang X, Allan F, Allen JE, Asano K, Babayan SA, Bah G,Beasley H, Bennett HM, Bisset SA, Castillo E, Cook J, Cooper PJ, Cruz-Bustos T, Cuéllar C, Devaney E, Doyle SR, Eberhard ML, Emery A, Eom KS, Gilleard JS, Gordon D, Harcus Y, Harsha B, Hawdon JM, Hill DE, Hodgkinson J, Horák P, Howe KL, Huckvale T, Kalbe M, Kaur G, Kikuchi T, Koutsovoulos G, Kumar S, Leach AR, Lomax J, Makepeace B, Matthews JB, Muro A, O’Boyle NM, Olson PD, Osuna A, Partono F, Pfarr K, Rinaldi G, Foronda P, Rollinson D, Samblas MG, Sato H, Schnyder M, Scholz T, Shafie M, Tanya VN, Toledo R, Tracey A, Urban JF, Wang L, Zarlenga D, Blaxter ML, Mitreva M & Berriman M).
Comparative genomics of the major parasitic worms.
Nature Genetics
[Wheeler NJ, Day TA, Zamanian M. GPCR identification in parasitic worm genome assemblies. Nature Protocol Exchange.]

2018 Brady SC, Evans KS, Bloom JS, Tanny RE, Cook DE, Giuliani S, Hippleheuser S, Zamanian M, Andersen EC .
Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses.

2018 Wheeler NJ, Dinguirard N, Marquez J, Gonzalez A, Zamanian M, Yoshino TP, Castillo MG .
Sequence and structural variation in the genome of the Biomphalaria glabrata embryonic (Bge) cell line.
Parasites & Vectors

2018 Fraser LM, Madriz I, Srinivasan D, Zamanian M, Bartholomay L, Kimber MJ.
Chemosensory structure and function in the filarial nematode, Brugia malayi.

2018 Harischandra H, Yuan W, Loghry HJ, Zamanian M, Kimber MJ .
Profiling extracellular vesicle release by the filarial nematode Brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin.
PLoS Negl Trop Dis

2018 Zamanian M, Cook DE, Zdraljevic S, Brady SC, Lee D, Lee J, Andersen EC .
Discovery of genomic intervals that underlie nematode responses to benzimidazoles.
PLoS Negl Trop Dis

2017 Lee D, Yang H, Kim J, Brady SC, Zdraljevic S, Zamanian M, Kim H, Paik Y, Krugliak L, Andersen EC , Lee J .
The genetic basis of natural variation in a phoretic behavior.
Nature Communications

2017 Harischandra DS, Ghaisas S, Rokada D, Zamanian M, Jin H, Anantharam V, Kimber MJ, Kanthasamy Aa, Kanthasamy An .
Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-Synuclein Misfolding in Metal Neurotoxicity.

Past (pre-Wisconsin) publications

2016 Zamanian M and Andersen EC .
Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector‐borne nematode diseases.
FEBS Journal

2015 Zamanian M §, Fraser L §, Agbedanu P, Harischandra H, Day TA, Bartholomay L, Kimber MJ .
Release of Small RNA-containing exosomes from the human filarial parasite Brugia malayi.
PLoS Negl Trop Dis

2015 Chan JD, Agbedanu PN, Grab T, Zamanian M, Yang Y, Li F, Dosa PI, Day TA, Marchant JS .
Ergot alkaloids (re)generate new leads as antiparasitics.
PLoS Negl Trop Dis

2015 Zamanighomi M §, Zamanian M §, Kimber M, Wang Z .
Gene regulatory network inference from perturbed time-series expression data via ordered dynamical expansion of non-steady state actors.
IEEE ACM Transactions on Computational Biology and Bioinformatics

2015 Wheeler NW, Kimber MJ, Ribero P, Day TA, Zamanian M .
Functional analysis of Girardia tigrina transcriptome seeds pipeline for antischistosomal discovery.
Parasites & Vectors

2014 Chan JD, Agbedanu PN, Zamanian M, Gruba SM, Haynes CL, Day TA, Marchant JS .
‘Death and axes’: unexpected Ca2+ entry phenologs predict new anti-schistosomal agents.
PLoS Pathogens

2014 Ciaran M, Atkinson LE, Zamanian M, McVeigh P, Day TA, Kimber MJ, Marks NJ, Maule AG, Mousley A .
New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches.
EuPA Open Proteomics

2013 Brewer MT, Agbedanu PN, Zamanian M, Day TA, Carlson S .
Evidence for a Bacterial Lipopolysaccharide-recognizing G protein-coupled Receptor in the Bacterial Engulfment by Entamoeba histolytica.
Eukaryotic Cell

2013 Tsai IJ, Zarowiecki M, Holroyd N, Garciarrubio A, Sanchez-Flores A, Brooks KL, Tracey A, Bobes RJ, Fragoso G, Sciutto E, Aslett M, Beasley H, Cai J, Camicia F, Clark R, Cucher M, De Silva N, Day TA, Deplazes P, Estrada K, Fernandez C, Holland PWH, Hou J, Hu S, Huckvale T, Hung SS, Kamenetzky L, Keane JA, Kiss F, Koziol U, Lambert O, Liu K, Luo X, Luo Y, Macchiaroli N, Nichol S, Paps J, Parkinson J, Stantcheva NP, Riddiford N, Rosenzvit M, Salinas G, Wasmuth JD, Zamanian M, Zheng Y, Cai X, Soberón X, Olson PD, Laclette JP , Brehm K , Berriman M .
The genomes of four tapeworm species reveal adaptations to parasitism.

2013 Atkinson L, Stevenson M, McCoy C, Maule AG, Marks NJ, Fleming C, Zamanian M, Day TA, Kimber MJ, Mousley A .
flp-32 ligand/receptor silencing phenocopy a faster phenotype in plant pathogenic nematodes.
PLoS Pathogens

2012 Zamanian M , Agbedanu PN, Wheeler NW, Kimber MJ, Day TA.
Novel RNAi-mediated approach to G protein-coupled receptor deorphanization: proof of principle and characterization of a planarian 5-HT receptor.
PLoS One

2011 Zamanian M , Kimber MJ, McVeigh P, Carlson SA, Maule AG, Day TA.
The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea.
BMC Genomics

2011 McVeigh P , Mair GR, Novozhilova E, Day A, Zamanian M, Marks NJ, Kimber MJ, Day TA, Maule AG.
Schistosome I/Lamides - A new family of bioactive helminth neuropeptides.
Int J Parasitol

2010 Novozhilova E, Kimber MJ, Qian H, McVeigh P, Robertson AP, Zamanian M, Maule AG, Day TA .
FMRFamide-like peptides (FLPs) enhance voltage-gated calcium currents to elicit muscle contraction in the human parasite Schistosoma mansoni.
PLoS Negl Trop Dis

2009 Berriman M , Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM .
The Genome of the blood fluke Schistosoma mansoni.
Nature (Cover Article)

2009 Kimber MJ , Sayegh L, El-Shehabi F, Song C, Zamanian M, Woods D, Day TA, Ribeiro P.
Identification of an Ascaris G protein-coupled acetylcholine receptor with atypical muscarinic pharmacology.
Int J Parasitol

2009 McVeigh P , Mair G, Atkinson L, Ladurner P, Zamanian M, Novozhilova E, Marks N, Day TA, Maule AG.
Discovery of multiple neuropeptide families in the phylum Platyhelminthes.
Int J Parasitol